6
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Intervención sobre el mecanismo de reconsolidación Translated title: Intervention on the Reconsolidation Mechanism

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          En la actualidad, existen tratamientos eficaces para reducir los síntomas de ansiedad y el malestar asociado. Sin embargo, se observa con frecuencia que las respuestas de ansiedad, después de haberse extinguido, se recuperan, sin que esté claro el mecanismo que subyace a dicha recuperación. Desde hace décadas, se considera la posibilidad de un mecanismo de reconsolidación que colaboraría en el proceso de almacenar nuevamente los recuerdos que han sido evocados. Algunas investigaciones recientes revelan que la intervención sobre el mecanismo de reconsolidación aparentemente previene la recuperación de respuestas de ansiedad que han sido previamente extinguidas. Si esto es así, podría ser una alternativa a los tratamientos actuales de los trastornos de ansiedad basados en la exposición. El objetivo del presente trabajo es revisar la evidencia sobre los efectos de actuar sobre el mecanismo de reconsolidación para la reducción de las respuestas de ansiedad. Finalmente se discuten las posibles implicaciones clínicas.

          Translated abstract

          At the present, effective treatments are available to reduce anxiety symptoms and their associated distress. Nevertheless, it is frequently observed that anxiety responses are recovered after extinction, without being clear the responsible mechanism of such phenomenon. For decades, it has been presumed the existence of a reconsolidation mechanism. Such mechanism is thought to participate in the re-storage of memories that have been evoked. Recent research apparently reveals that intervention on reconsolidation mechanisms prevents the recovery of anxiety responses that have been previously extinguished. Intervention on these mechanisms could represent an alternative to current psychological treatments for anxiety disorders based on exposure procedures. The objective of the present work is to review the evidence on reconsolidation mechanisms and its effects on the reduction of anxiety responses. Finally some clinical implications will be discussed.

          Related collections

          Most cited references47

          • Record: found
          • Abstract: found
          • Article: not found

          The molecular biology of memory storage: a dialogue between genes and synapses.

          E R Kandel (2001)
          One of the most remarkable aspects of an animal's behavior is the ability to modify that behavior by learning, an ability that reaches its highest form in human beings. For me, learning and memory have proven to be endlessly fascinating mental processes because they address one of the fundamental features of human activity: our ability to acquire new ideas from experience and to retain these ideas over time in memory. Moreover, unlike other mental processes such as thought, language, and consciousness, learning seemed from the outset to be readily accessible to cellular and molecular analysis. I, therefore, have been curious to know: What changes in the brain when we learn? And, once something is learned, how is that information retained in the brain? I have tried to address these questions through a reductionist approach that would allow me to investigate elementary forms of learning and memory at a cellular molecular level-as specific molecular activities within identified nerve cells.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Context and behavioral processes in extinction.

            This article provides a selective review and integration of the behavioral literature on Pavlovian extinction. The first part reviews evidence that extinction does not destroy the original learning, but instead generates new learning that is especially context-dependent. The second part examines insights provided by research on several related behavioral phenomena (the interference paradigms, conditioned inhibition, and inhibition despite reinforcement). The final part examines four potential causes of extinction: the discrimination of a new reinforcement rate, generalization decrement, response inhibition, and violation of a reinforcer expectation. The data are consistent with behavioral models that emphasize the role of generalization decrement and expectation violation, but would be more so if those models were expanded to better accommodate the finding that extinction involves a context-modulated form of inhibitory learning.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace.

              Rats had a memory loss of a fear response when they received an electroconvulsive shock 24 hours after the fear-conditioning trial and preceded by a brief presentation of the conditioned stimulus. No such loss occurred when the conditioned stimulus was not presented. The memory loss in animals given electroconvulsive shock 24 hours after conditioning was, furthermore, as great as that displayed in animals given electroconvulsive shock immediately after conditioning. This result throws doubt on the assertion that electroconvulsive shock exerts a selective amnesic effect on recently acquired memories and thus that electroconvulsive shock produces amnesia solely through interference with memory trace consolidation.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                up
                Universitas Psychologica
                Univ. Psychol.
                Pontificia Universidad Javeriana
                1657-9267
                September 2015
                : 14
                : 3
                : 961-966
                Affiliations
                [1 ] Universidad Complutense de Madrid España
                [2 ] Universidad de la Sabana Colombia
                Article
                S1657-92672015000300013
                10.11144/Javeriana.upsy14-3.ismr
                fefcd29c-e15b-4f60-b8c5-9d0ba7d8cf9f

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                Product

                SciELO Colombia

                Self URI (journal page): http://pepsic.bvsalud.org/scielo.php?script=sci_serial&pid=1657-9267&lng=en

                Reconsolidación,extinción,condicionamiento de miedo,trastornos de ansiedad,reconsolidation,extinction,fear conditioning,anxiety disorders

                Comments

                Comment on this article