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      Immunoneutralization of Oxytocin Attenuates Preovulatory Prolactin Secretion during Proestrus in the Rat

      Neuroendocrinology

      S. Karger AG

      Passive immunoneutralization, Oxytocin, Prolactin

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          Abstract

          Recent studies have demonstrated that oxytocin (OT) stimulates prolactin (PRL) release from the anterior pituitary gland and that the secretion of OT into pituitary portal blood changes during the rat estrous cycle. To better define the role of OT on PRL release during the reproductive cycle, the effect of administration of antiserum specific for OT on preovulatory PRL secretion in female rats was studied. Intravenous injection of OT antiserum into cyclic female rats between 13.30 and 14.00 h of proestrus neutralized the elevated levels of OT in pituitary portal blood and significantly reduced the subsequent PRL surge. The characteristic proestrous surge of luteinizing hormone (LH) was not affected by the OT antiserum treatment. These data support a physiological role for OT in the regulation of PRL release during the reproductive cycle.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 48
          : 2
          : 214-216
          Affiliations
          Department of Reproductive Medicine, University of California at San Diego, La Jolla, Calif., USA
          Article
          125012 Neuroendocrinology 1988;48:214–216
          10.1159/000125012
          3221983
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Rapid Communication

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