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Abstract
To determine whether responsivity of reward circuitry to food predicts future increases
in body mass and whether polymorphisms in DRD2 and DRD4 moderate these relations.
The functional magnetic resonance imaging (fMRI) paradigm investigated blood oxygen
level dependent activation in response to imagined intake of palatable foods, unpalatable
foods, and glasses of water shown in pictures. DNA was extracted from saliva samples
using standard salting-out and solvent precipitation methods.
Forty-four adolescent female high school students ranging from lean to obese.
Future increases in body mass index (BMI).
Weaker activation of the frontal operculum, lateral orbitofrontal cortex, and striatum
in response to imagined intake of palatable foods, versus imagined intake of unpalatable
foods or water, predicted future increases in body mass for those with the DRD2 TaqIA
A1 allele or the DRD4-7R allele. Data also suggest that for those lacking these alleles,
greater responsivity of these food reward regions predicted future increases in body
mass.
This novel prospective fMRI study indicates that responsivity of reward circuitry
to food increases risk for future weight gain, but that genes that impact dopamine
signaling capacity moderate the predictive effects, suggesting two qualitatively distinct
pathways to unhealthy weight gain based on genetic risk.
2010 Elsevier Inc. All rights reserved.