0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Urinary Prostaglandins E 2 and F in Chronic Renal Failure

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The role played by renal prostaglandins E<sub>2</sub> (PGE<sub>2</sub>) and F<sub>2α</sub>(PGF<sub>2α</sub>) in the modification of sodium homeostasis in chronic renal failure (CFR) was studied. The 24-hour urinary excretion of PGE<sub>2</sub> and PGF<sub>2α</sub> was measured before and after 5 days of a diet containing less than 20 mmol/day of sodium in 6 patients with CRF. At the end of this period, an acute sodium load (77 mmol/h of NaCl for 4 h) was administered and prostaglandins measured in hourly urine collections. In contrast to the findings previously reported in normal subjects, PGE<sub>2</sub> and PGF<sub>2α </sub>decreased with the low-sodium diet. The ratio PGE<sub>2</sub> / PGF<sub>2α</sub> (reflecting the activity of the enzyme PGE<sub>2–</sub>9-ketoreductase) was greatly increased and did not change with the low-sodium diet. The acute sodium load induced an increase in urinary prostaglandins. The results suggest that prostaglandins may contribute to natriuresis in CRF, under basal conditions, after a short-term sodium depletion and in response to an acute sodium load. The changes in prostaglandin excretion in CRF could be related to decreased activity of PGE<sub>2–</sub>9-ketoreductase.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          24 December 2008
          : 40
          : 2
          : 152-154
          Affiliations
          Department of Nephrology, Meir Hospital, Kfar Saba and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
          Article
          183452 Nephron 1985;40:152–154
          10.1159/000183452
          3858702
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 3
          Categories
          Original Paper

          Comments

          Comment on this article