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Routine Nebulized Ipratropium and Albuterol Together Are Better Than Either Alone in COPD

Chest

American College of Chest Physicians

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      Most cited references 15

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      Fifteen-year interval spirometric evaluation of the Oregon predictive equations.

      The 1969 Oregon spirometric predictive equations were evaluated by retesting 199 of the 988 original sample population after 15 years. The 1969 data were used to test for sample bias between the retested and not-retested groups. There was no significant difference in mean values for age, height, or test results except for a five-year age difference in men. Regression analysis of residuals and the differences between calculated and predicted values of annual decrements of FVC, FEV1, and FEF25-75% on age revealed no statistically significant age trend. Although residual means were statistically significant for FVC and FEV1 for men and FVC and FEF25-75% for women, the differences between calculated and predicted annual decrements were significant only for women in FEF25-75%. Although group performance was accurately predicted for most tests, test SDs and SEMs demonstrated considerable individual variation. Lower limits of normality are suggested to assist in evaluating previously-tested patients.
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        Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma.

        The effects of inhaling 200 mu g of salbutamol were compared with those of inhaling 40 mu g of ipratropium bromide singly and in combination with salbutamol in eight patients with bronchitis and eight asthmatic patients in a double-blind controlled trial. Changes in airways resistance were assessed by measuring the forced expiratory volume in 1 second and specific airways conductance. Both drugs were significantly better in relieving airways obstruction than placebo. Salbutamol was significantly more effective than ipratropium bromide in patients with asthma, but in the patients with bronchitis there was no significant difference between salbutamol and ipratropium bromide. The combination of the two drugs produced a slightly greater and longer response than either drug alone but this was not significant.
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          Management of chronic obstructive pulmonary disease.

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            Author and article information

            Journal
            Chest
            Chest
            American College of Chest Physicians
            00123692
            December 1997
            December 1997
            : 112
            : 6
            : 1514-1521
            10.1378/chest.112.6.1514
            © 1997

            http://www.elsevier.com/tdm/userlicense/1.0/

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