Blog
About

10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Transformation to small-cell lung cancer as a mechanism of acquired resistance to crizotinib and alectinib.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A 56-year-old woman, a never-smoker, had postoperative recurrence of anaplastic lymphoma kinase rearranged lung cancer. She achieved a partial response to treatment with an anaplastic lymphoma kinase tyrosine kinase inhibitor, crizotinib. After the tumor regrowth, crizotinib was switched to alectinib; once again a partial response was observed. At the second recurrence, transbronchial needle aspiration of the right paratracheal node was performed, which revealed cytological findings of small-cell carcinoma. While treatment with cisplatin-irinotecan chemotherapy made reduction of some tumor shadows, including the biopsied mediastinal lymph nodes, new, small, nodular shadows, highly suggestive of pulmonary metastases, were detected in both lung fields. This case may show proof of the transformation to small-cell lung cancer as a mechanism of resistance to anaplastic lymphoma kinase tyrosine kinase inhibitors in anaplastic lymphoma kinase rearranged tumor. However, this transformation may also be only one part of the resistance mechanism of the heterogeneous tumor.

          Related collections

          Author and article information

          Journal
          Jpn. J. Clin. Oncol.
          Japanese journal of clinical oncology
          Oxford University Press (OUP)
          1465-3621
          0368-2811
          Feb 2016
          : 46
          : 2
          Affiliations
          [1 ] Department of Medical Oncology, Japanese Red Cross Medical Center, Shibuya, Tokyo aaa17580@pop06.odn.ne.jp.
          [2 ] Department of Respiratory Medicine, Japanese Red Cross Medical Center, Shibuya, Tokyo.
          [3 ] Department of Thoracic Surgery, Japanese Red Cross Medical Center, Shibuya, Tokyo.
          [4 ] Department of Pathology, Japanese Red Cross Medical Center, Shibuya, Tokyo, Japan.
          Article
          hyv173
          10.1093/jjco/hyv173
          26613679

          Comments

          Comment on this article