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      Bopindolol for the Treatment of Chronic Stable Angina pectoris - A Clinical Study of the Relationship between Dose and Effect

      a , a , b


      S. Karger AG

      Stable angina pectoris, Exercise testing, Beta-blockade, Bopindolol

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          Following a 4-week placebo period, 19 patients (12 male, average age 62.3 years) with chronic stable angina pectoris and a positive exercise test were treated with the beta-adrenoceptor antagonist bopindolol at increasing doses of 0.5, 1 and 2 mg, each being given once daily for 4 weeks. For the final 4 weeks of the study, active treatment was replaced by placebo. Maximum tolerated exercise (bicycle ergometry, performed 24 h after drug administration) increased dose-dependently from 519 ± 59 s (baseline) to 758 ± 95s with 2 mg (p < 0.001) and fell again to 508 ± 48 s (placebo). The frequency of anginal attacks also fell dose-dependently from an average of 5.4 per week (baseline) to 0.5 with 2 mg (p < 0.001) and rose again to 5.1 per week when active treatment was stopped.

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          Author and article information

          S. Karger AG
          12 November 2008
          : 77
          : 6
          : 459-465
          aClinical Research Department, Sandoz Ltd., Basel, Switzerland; bMedical Director (retired), Clinic for Cardiac and Circulatory Diseases, Tegernsee, FRG
          174638 Cardiology 1990;77:459–465
          © 1990 S. Karger AG, Basel

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          Pages: 7
          Original Paper


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