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      Wnt signaling in development and tissue homeostasis.

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          Abstract

          The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.

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          Author and article information

          Journal
          Development
          Development (Cambridge, England)
          The Company of Biologists
          1477-9129
          0950-1991
          June 08 2018
          : 145
          : 11
          Affiliations
          [1 ] University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada.
          [2 ] University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada stephane.angers@utoronto.ca.
          Article
          145/11/dev146589
          10.1242/dev.146589
          29884654
          ff4af243-535f-4895-84ab-2f81c50117b6

          Wnt signaling, Epigenetics, Wnt protein

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