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      Depressive symptoms at HIV testing and two-year all-cause mortality among men who inject drugs in Vietnam

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          Abstract

          People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with two-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the two years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the two-year risk of death among those with depressive symptoms was 9.7% (95% CI: −1.2%-20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the two-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5%-19.7%), 13.9% (4.6%-23.2%), and 11.0% (0.9%-21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population.

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          Author and article information

          Journal
          9712133
          21042
          AIDS Behav
          AIDS Behav
          AIDS and behavior
          1090-7165
          1573-3254
          25 October 2018
          March 2019
          01 March 2020
          : 23
          : 3
          : 609-616
          Affiliations
          [1 ]University of North Carolina, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill NC, USA
          [2 ]University of North Carolina, Gillings School of Global Public Health, Department of Health Behavior, Chapel Hill NC, USA
          [3 ]Thai Nguyen Center for Preventive Medicine, Thai Nguyen, Vietnam
          [4 ]Johns Hopkins Bloomberg School of Public Health, Department of Health, Behavior and Society, Baltimore MD, USA
          [5 ]Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore MD, USA
          [6 ]Johns Hopkins Bloomberg School of Public Health, Department of Biostatistics, Baltimore MD, USA
          Author notes
          [* ]Correspondence to Sara N. Levintow, Department of Epidemiology, 135 Dauer Drive, 2101 McGavran-Greenberg Hall, Chapel Hill, NC 27599. Phone: 240-750-5029 levintow@ 123456email.unc.edu
          Article
          PMC6408284 PMC6408284 6408284 nihpa1510513
          10.1007/s10461-018-2318-8
          6408284
          30357641
          ff7c068b-f6b6-43c4-b25a-d721ba922b9d
          History
          Categories
          Article

          HIV,depression,Vietnam,mortality,injection drug use
          HIV, depression, Vietnam, mortality, injection drug use

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