3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Antibody response to collagen after functional implantation of different polyester vascular prostheses in pigs.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Besides inflammation, specific immune responses are seen also after implantation of biomaterials. The aim was to investigate the humoral response to bovine collagen type I following implantation of various polyester (Dacron) prostheses into pigs. In 24 randomized pigs, the infrarenal aorta was replaced with a segment of collagen-impregnated, woven polyester prosthesis of low, medium, or high porosity. IgG antibodies were detected by immunoassay using native and denatured collagen type I as a target for blood samples taken on day 1 (implantation), 10, 17, 24, 62, and 116. As generally observed, antibodies to native and denatured collagen are of low titer and were significantly correlated with enhanced binding to the denatured form (p < 0.001). The highest overall antibody prevalence to native and denatured collagen was obtained on day 116 with 68% and on day 62 with 59%, respectively. Prostheses with high porosity induced an early immune response on day 10; those with low and medium porosity induced the highest antibody levels later after 2 months. Collagen antibodies neither correlated with serum IgG contents nor with antibodies to the prosthesis polyester matrix. Thus, humoral immune response against implant components may provide a further parameter in describing biocompatibility but also a potential marker that may facilitate monitoring of individual perigraft reaction.

          Related collections

          Author and article information

          Journal
          J Biomed Mater Res A
          Journal of biomedical materials research. Part A
          Wiley
          1549-3296
          1549-3296
          Mar 01 2005
          : 72
          : 3
          Affiliations
          [1 ] Institute of Pathophysiology of the Ernst Moritz Arndt University Greifswald, Karlsburg D-17495, Germany. schlosse@uni-greifswald.de
          Article
          10.1002/jbm.a.30240
          15654697
          ff7d5fe9-2b11-4cf0-b675-a5da6413b9bd
          History

          Comments

          Comment on this article