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Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial.
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Abstract
Infections are a leading cause of death in patients with acute CNS injury such as stroke. Recent experimental evidence indicated that stroke leads to suppression of innate and adaptive peripheral immune responses which predisposes to infection. However, less is known on phenotypic and functional immune alterations in correlation with the occurrence of infectious complications in patients with acute stroke.