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      Effects of Sex Hormones on Hepatic Aldehyde Oxidase Activity in C57BL/6J Mice

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          The effects of sex hormones on the activity of a hepatic enzyme, aldehyde oxidase (EC, an oxidoreductase), in sexually immature and mature C57BL/6J mice has been investigated. The androgens testosterone propionate and dihydrotestosterone significantly increased enzyme levels in castrated adult males and intact adult females, whereas β-estradiol-3,17-dipropionate significantly decreased enzyme levels in adult male mice. Increased levels of aldehyde oxidase could not be achieved in immature males with either androgen. Sucrose density gradient ultracentrifugation of hepatic cytosol and <sup>3</sup>H-androgen revealed a macromolecular binding complex sedimenting at 4.6 S which, by careful examination, appeared to represent serum contamination of the cytosol preparation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 14
          : 4
          : 250-259
          Department of Medicine/Division of Endocrinology, The Milton Hershey Medical Center of the Pennsylvania State University, Hershey, Pa., and Department of Biology, Pennsylvania State University, University Park, Pa., USA
          179395 Horm Res 1981;14:250–259
          © 1981 S. Karger AG, Basel

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          Pages: 10
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