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      Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

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          Abstract

          Genetically encoded tools for visualizing and manipulating neurons in vivo have led to significant advances in neuroscience, in large part because of the ability to target expression to specific cell populations of interest. Current methods enable targeting based on marker gene expression, development, anatomical projection pattern, synaptic connectivity, and recent activity as well as combinations of these factors. Here, we review these methods, focusing on issues of practical implementation as well as areas for future improvement.

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          Author and article information

          Journal
          0117605
          668
          Annu Rev Genet
          Annu. Rev. Genet.
          Annual review of genetics
          0066-4197
          1545-2948
          26 May 2017
          06 October 2016
          23 November 2016
          06 October 2017
          : 50
          : 571-594
          Affiliations
          [1 ]Department of Psychiatry, New York University School of Medicine, New York, NY 10016
          [2 ]Department of Neuroscience and Physiology, Smilow Neuroscience Program, and New York University Neuroscience Institute, New York, NY 10016
          [3 ]Centre for Neural Circuits and Behavior, University of Oxford, Oxford, OX1 3SR, United Kingdom
          Author notes
          [4]

          Present address: Tata Institute of Fundamental Research, Mumbai, 400005, India

          Article
          PMC5630135 PMC5630135 5630135 nihpa879459
          10.1146/annurev-genet-120215-035011
          5630135
          27732792
          ffa235bb-d9df-4476-81b4-ec90324ae91f
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