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      Detection of IgAl-Dominant Immune Complexes in Peripheral Blood Polymorphonuclear Leukocytes by Double Immunofluorescence in Patients with IgA Nephropathy

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          Abstract

          The amounts of IgA1- and/or IgA2-dominant immune complexes included in peripheral blood polymorphonuclear cells (PMN) were determined by the double immunofluorescence technique in patients with IgA nephropathy. The aim of the present study was to determine the prevalence of IgA1- and/or IgA2-dominant immune complexes phagocytized by PMN in patients with IgA nephropathy. 5 patients with IgA nephropathy and 10 healthy adults were examined. It was demonstrated that the percentages of IgA1 with C3 cytoplasmic inclusion bodies were significantly increased compared with those of IgA2 with C3 cytoplasmic inclusion bodies in patients with IgA nephropathy. It was suggested that IgAl -dominant immune complexes are phagocytized by peripheral blood PMN in patients with IgA nephropathy.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          04 December 2008
          : 37
          : 2
          : 137-139
          Affiliations
          Department of Internal Medicine, School of Medicine, Tokai University, Isehara City, Japan
          Article
          183230 Nephron 1984;37:137–139
          10.1159/000183230
          6374482
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Short Communication

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