Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ.

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Abstract

To study the role of IFN-γ in the pathogenesis of systemic JIA (sJIA) and haemophagocytic lymphohistiocytosis (HLH) by searching for an IFN-γ profile, and to assess its relationship with other cytokines.

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Journal

Journal ID (iso-abbrev): Rheumatology (Oxford)

Title: Rheumatology (Oxford, England)

ISSN (Electronic): 1462-0332

ISSN (Print): 1462-0324

Publication date (Electronic): Aug 2015

Volume: 54

Issue: 8

Affiliations

[1 ] Laboratory of Immunobiology.

[2 ] Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium.

[3 ] IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France.

[4 ] Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, University of Leuven, Department of Rheumatology, University Hospital Leuven, Leuven, Belgium.

[5 ] Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

[6 ] Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.

[7 ] Laboratory of Pediatric Immunology, University Hospital Leuven, University of Leuven and.

[8 ] Department of Imaging and Pathology, University of Leuven, Leuven, Belgium.

[9 ] IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France, Laboratory of Pediatric Immunology, University Hospital Leuven, University of Leuven and.

[10 ] Laboratory of Immunobiology, patrick.matthys@rega.kuleuven.be.

Article

Publisher Item ID: keu524

DOI: 10.1093/rheumatology/keu524

PubMed ID: 25767156

SO-VID: ffa4d749-2ff9-42ec-bdd9-3e1eedc41e0c

History

Keywords: IFN-γ,IL-18,cytokine,haemophagocytic lymphohistiocytosis,macrophage activation syndrome,peripheral blood mononuclear cells,plasma,systemic juvenile idiopathic arthritis

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Keywords: IFN-γ, IL-18, cytokine, haemophagocytic lymphohistiocytosis, macrophage activation syndrome, peripheral blood mononuclear cells, plasma, systemic juvenile idiopathic arthritis

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