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      When Is the Hippocampus Involved in Recognition Memory?

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      The Journal of Neuroscience
      Society for Neuroscience

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          Abstract

          The role of the hippocampus in recognition memory is controversial. Recognition memory judgments may be made using different types of information, including object familiarity, an object's spatial location, or when an object was encountered. Experiment 1 examined the role of the hippocampus in recognition memory tasks that required the animals to use these different types of mnemonic information. Rats with bilateral cytotoxic lesions in the hippocampus or perirhinal or prefrontal cortex were tested on a battery of spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference); object–place information (object-in-place memory), or recency information (temporal order memory). Experiment 2 examined whether, when using different types of recognition memory information, the hippocampus interacts with either the perirhinal or prefrontal cortex. Thus, groups of rats were prepared with a unilateral cytotoxic lesion in the hippocampus combined with a lesion in either the contralateral perirhinal or prefrontal cortex. Rats were then tested in a series of object recognition memory tasks. Experiment 1 revealed that the hippocampus was crucial for object location, object-in-place, and recency recognition memory, but not for the novel object preference task. Experiment 2 revealed that object-in-place and recency recognition memory performance depended on a functional interaction between the hippocampus and either the perirhinal or medial prefrontal cortices. Thus, the hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneuro
          jneurosci
          J. Neurosci
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          20 July 2011
          : 31
          : 29
          : 10721-10731
          Affiliations
          [1]Medical Research Council Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
          Author notes
          Correspondence should be addressed to Dr. Elizabeth C. Warburton, School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. e.c.warburton@ 123456bristol.ac.uk

          Author contributions: E.C.W. designed research; G.R.I.B. and E.C.W. performed research; G.R.I.B. analyzed data; E.C.W. wrote the paper.

          Article
          PMC6622630 PMC6622630 6622630 3709891
          10.1523/JNEUROSCI.6413-10.2011
          6622630
          21775615
          ffc44131-a2a7-40b3-9d97-494f77327c43
          Copyright © 2011 the authors 0270-6474/11/3110721-11$15.00/0
          History
          : 9 December 2010
          : 23 May 2011
          : 3 June 2011
          Categories
          Articles
          Behavioral/Systems/Cognitive

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