Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly
skin and joint manifestations affecting approximately 2% of the population. In this
first of 5 sections of the guidelines of care for psoriasis, we discuss the classification
of psoriasis; associated comorbidities including autoimmune diseases, cardiovascular
risk, psychiatric/psychologic issues, and cancer risk; along with assessment tools
for skin disease and quality-of-life issues. Finally, we will discuss the safety and
efficacy of the biologic treatments used to treat patients with psoriasis.