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Mechanisms linking obesity to insulin resistance and type 2 diabetes.

Nature

physiopathology, genetics, complications, Obesity, pathology, Islets of Langerhans, Insulin Resistance, Humans, etiology, Diabetes Mellitus, Type 2

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      Abstract

      Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet beta-cells - the cells that release insulin - failure to control blood glucose levels results. Abnormalities in beta-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.

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      Journal
      10.1038/nature05482
      17167471

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