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Correlation Between Hypertension, C-Reactive Protein and Serum Uric Acid With Psychological Well-being

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      Multiple population-based human studies have established a strong association between increasing levels of serum C-reactive protein, uric acid and subsequent development of hypertension.


      We aimed to investigate the association between mental well-being with presence of hypertension, hyperuricemia and hs-CRP levels. ‬‬

      Patients and Methods:

      This was a cross sectional study of 801 individuals aged 35-85 years old in Broujerd, Iran, included by randomized cluster sampling. General Health Questionnaire (GHQ-12) for assessing mental health/distress level, MONICA standard questions for evaluating hypertension history, serum hs-CRP and Serum Uric Acid (SUA) were evaluated Data were analyzed by appropriate statistical test such as chi-square, T-test and correlation.


      One hundred eighty five patients (23.1%) had high distress/minor psychiatric disorders. SUA had significant association with hypertension (r = 0.64, P = 0.034). No significant relation was observed between hs-CRP and hypertension. The correlation between GHQ and hs-CRP was not significant but a weak and negative correlation was found between GHQ and SUA SUA (P = 0.012, r = -0.089).


      The weak and strong correlation among these parameters indicate that mental wellbeing relays on physical wellness and interact with each other; therefore, controlling hypertension along with uric acid control may effect mental health of any kind of patients.

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      Most cited references 21

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      Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.

      To provide a single source for the best available estimates of the US prevalence of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as the symptoms of neck and back pain. A companion article (part I) addresses additional conditions. The National Arthritis Data Workgroup reviewed published analyses from available national surveys, such as the National Health and Nutrition Examination Survey and the National Health Interview Survey. Because data based on national population samples are unavailable for most specific rheumatic conditions, we derived estimates from published studies of smaller, defined populations. For specific conditions, the best available prevalence estimates were applied to the corresponding 2005 US population estimates from the Census Bureau, to estimate the number affected with each condition. We estimated that among US adults, nearly 27 million have clinical osteoarthritis (up from the estimate of 21 million for 1995), 711,000 have polymyalgia rheumatica, 228,000 have giant cell arteritis, up to 3.0 million have had self-reported gout in the past year (up from the estimate of 2.1 million for 1995), 5.0 million have fibromyalgia, 4-10 million have carpal tunnel syndrome, 59 million have had low back pain in the past 3 months, and 30.1 million have had neck pain in the past 3 months. Estimates for many specific rheumatic conditions rely on a few, small studies of uncertain generalizability to the US population. This report provides the best available prevalence estimates for the US, but for most specific conditions more studies generalizable to the US or addressing understudied populations are needed.
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        The 12-item General Health Questionnaire (GHQ-12): translation and validation study of the Iranian version

        Background The objective of this study was to translate and to test the reliability and validity of the 12-item General Health Questionnaire (GHQ-12) in Iran. Methods Using a standard 'forward-backward' translation procedure, the English language version of the questionnaire was translated into Persian (Iranian language). Then a sample of young people aged 18 to 25 years old completed the questionnaire. In addition, a short questionnaire containing demographic questions and a single measure of global quality of life was administered. To test reliability the internal consistency was assessed by Cronbach's alpha coefficient. Validity was performed using convergent validity. Finally, the factor structure of the questionnaire was extracted by performing principal component analysis using oblique factor solution. Results In all 748 young people entered into the study. The mean age of respondents was 21.1 (SD = 2.1) years. Employing the recommended method of scoring (ranging from 0 to 12), the mean GHQ score was 3.7 (SD = 3.5). Reliability analysis showed satisfactory result (Cronbach's alpha coefficient = 0.87). Convergent validity indicated a significant negative correlation between the GHQ-12 and global quality of life scores as expected (r = -0.56, P < 0.0001). The principal component analysis with oblique rotation solution showed that the GHQ-12 was a measure of psychological morbidity with two-factor structure that jointly accounted for 51% of the variance. Conclusion The study findings showed that the Iranian version of the GHQ-12 has a good structural characteristic and is a reliable and valid instrument that can be used for measuring psychological well being in Iran.
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          National Arthritis Data Work-group. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II


            Author and article information

            [1 ]School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IR Iran
            [2 ]Psychiatry Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran
            [3 ]School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
            [4 ]Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
            [5 ]Azna Health Services Center, Lorestan University of Medical Sciences, Azna, IR Iran
            [6 ]Imam Khomeini Hospital, Lorestan University of Medical Sciences, Borujerd, IR Iran
            [7 ]School of Nursing, Lorestan University of Medical Sciences, Aligudarz, IR Iran
            Author notes
            [* ]Corresponding Author: Ali Maleki, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IR Iran. Tel: +98-9161623573, E-mail: Maleki.a@
            Iran Red Crescent Med J
            Iran Red Crescent Med J
            Iranian Red Crescent Medical Journal
            05 July 2014
            July 2014
            : 16
            : 7
            4166100 10.5812/ircmj.17205
            Copyright © 2014, Iranian Red Crescent Medical Journal; Published by Kowsar Corp.

            This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            Research Article


            uric acid, mental health, c - reactive protein, hypertension


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