We present the first record of Gomesa leinigii (Pabst) M.W. Chase & N.H. Williams in São Paulo state, Brazil, previously known only in the state of Paraná, extended its geographical distribution. We also document newly discovered populations of Macradenia paraensis Barb.Rodr. and Peperomia psilostachya C.DC. in São Paulo state, Brazil. Description, comments, conservation status, photographic figures and a distribution map of these species are presented.