To examine whether there were any ethnic-racial differences among 144 HIV-infected gay men (47 Caucasian, 48 African-American, and 49 Puerto Rican) on psychological stressors related to the gay lifestyle, responses to the Gay Lifestyle Hassles scale were analyzed. The African-American and Puerto Rican men reported significantly higher scores on frequency of Gay lifestyle Hassles and cumulated severity of Gay Lifestyle Hassles over-all than Caucasian men. The results suggest that HIV-infected ethnic-minority gay men were more prone to psychological stress related to the gay lifestyle than HIV-infected Caucasian gay men, which may have negative consequences for their mental and physical health.