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      The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer – a multicentre observational study

      1 , 2 , 3 , 3 , 4 , 3 , 5 , 3 , 6 , 7 , 3 , 8 , 3 , 9 , 3 , 10 , 3 , 11 , 3 , 12 , 3 , 5 , 13 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 21 , 22 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 2 , 29 , 30 , 26 , 31 , 32 , 32 , 1 , 33 , 34 , 3 , 35 , 36 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , IDENTIFY Study group
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          Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

          Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bias, uncertainty intervals are now provided for the estimated sex- and site-specific all-ages number of new cancer cases and cancer deaths. We briefly describe the key results globally and by world region. There were an estimated 18.1 million (95% UI: 17.5-18.7 million) new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million (95% UI: 9.3-9.8 million) deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018.
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            The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.

            The fourth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "blue book"), published in 2016, contains significant revisions. These revisions were performed after consideration by a large international group of pathologists with special expertise in this area. A subgroup of these persons met at the WHO Consensus Conference in Zurich, Switzerland, in 2015 to finalize the revisions. This review summarizes the most significant differences between the newly published classification and the prior version for renal, penile, and testicular tumours. Newly recognized epithelial renal tumours are hereditary leiomyomatosis and renal cell carcinoma (RCC) syndrome-associated RCC, succinate dehydrogenase-deficient RCC, tubulocystic RCC, acquired cystic disease-associated RCC, and clear cell papillary RCC. The WHO/International Society of Urological Pathology renal tumour grading system was recommended, and the definition of renal papillary adenoma was modified. The new WHO classification of penile squamous cell carcinomas is based on the presence of human papillomavirus and defines histologic subtypes accordingly. Germ cell neoplasia in situ (GCNIS) of the testis is the WHO-recommended term for precursor lesions of invasive germ cell tumours, and testicular germ cell tumours are now separated into two fundamentally different groups: those derived from GCNIS and those unrelated to GCNIS. Spermatocytic seminoma has been designated as a spermatocytic tumour and placed within the group of non-GCNIS-related tumours in the 2016 WHO classification.
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              The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

              Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalizability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case-control and cross-sectional studies. We convened a 2-day workshop in September 2004, with methodologists, researchers, and journal editors to draft a checklist of items. This list was subsequently revised during several meetings of the coordinating group and in e-mail discussions with the larger group of STROBE contributors, taking into account empirical evidence and methodological considerations. The workshop and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE Statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles. 18 items are common to all three study designs and four are specific for cohort, case-control, or cross-sectional studies. A detailed "Explanation and Elaboration" document is published separately and is freely available on the web sites of PLoS Medicine, Annals of Internal Medicine, and Epidemiology. We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies.
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                Author and article information

                Contributors
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                Journal
                BJU International
                BJU Int
                Wiley
                1464-4096
                1464-410X
                October 2021
                September 08 2021
                October 2021
                : 128
                : 4
                : 440-450
                Affiliations
                [1 ]Health Services Research Unit University of Aberdeen AberdeenUK
                [2 ]Aberdeen Royal Infirmary Aberdeen UK
                [3 ]British Urology Researchers in Surgical Training (BURST) Collaborative London UK
                [4 ]Department of Clinical Surgery Western General Hospital University of Edinburgh EdinburghUK
                [5 ]Freeman Hospital Newcastle Upon TyneUK
                [6 ]Dept. of Surgery and Cancer Charing Cross Hospital Imperial College Healthcare NHS Trust LondonUK
                [7 ]Division of Surgery Department of Surgery and Cancer Imperial College London LondonUK
                [8 ]Addenbrooke’s Hospital Cambridge University Hospitals NHS Foundation Trust CambridgeUK
                [9 ]Wrexham Maelor Hospital WrexhamUK
                [10 ]Torbay and South Devon NHS Foundation Trust TorbayUK
                [11 ]Department of Urology Whipps Cross Hospital Barts Health NHS Trust LondonUK
                [12 ]Morriston Hospital Swansea UK
                [13 ]Department of Urologic Sciences University of British Columbia Vancouver BC Canada
                [14 ]Department of Surgical Sciences Città della Salute e della Scienza TurinItaly
                [15 ]University of Turin TurinItaly
                [16 ]SanGiovanni Battista Hospital Turin Italy
                [17 ]Department of Urology La Paz University Hospital Madrid Spain
                [18 ]Urology Department Claude Huriez Hospital CHU Lille Lille France
                [19 ]Division of Urology Department of Surgery University of Alberta Edmonton AB Canada
                [20 ]Department of Urology Istanbul Medeniyet University IstanbulTurkey
                [21 ]Urological Clinic Department of Medicine, Surgery and Health Sciences University of Trieste Trieste Italy
                [22 ]University Hospitals of Derby and Burton NHS Foundation Trust DerbyUK
                [23 ]Department of Urology Queen Alexandra Hospital PortsmouthUK
                [24 ]Salford Royal NHS Foundation Trust SalfordUK
                [25 ]Doncaster Royal Infirmary Doncaster UK
                [26 ]University of North Carolina Hospitals Chapel Hill NC USA
                [27 ]Department of Urology Hospital Universitario Cruces Barakaldo Spain
                [28 ]Bradford Teaching Hospitals NHS Foundation Trust BradfordUK
                [29 ]Great Western Hospitals NHS Foundation Trust SwindonUK
                [30 ]Frimley Renal Cancer Centre Frimley Hospitals NHS Foundation Trust Camberley UK
                [31 ]Test Evaluation Research Group Institute of Applied Health Research University of Birmingham NIHR Birmingham Biomedical Research Centre University Hospitals Birmingham NHS Foundation Trust and University of Birmingham BirminghamUK
                [32 ]Test Evaluation Research Group Institute of Applied Health Research University of Birmingham BirminghamUK
                [33 ]University of Exeter Medical School ExeterUK
                [34 ]Royal Devon and Exeter NHS Foundation Trust Exeter UK
                [35 ]Division of Surgery and Interventional Science University College London LondonUK
                [36 ]Department of Urology University College London Hospitals NHS Foundation Trust London UK
                Article
                10.1111/bju.15483
                33991045
                fffee738-6bfc-4377-94ea-c45488b7cd1c
                © 2021

                http://creativecommons.org/licenses/by-nc/4.0/

                http://doi.wiley.com/10.1002/tdm_license_1.1

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