Blog
About

Stress signalling in stem cells

How do stem cells maintain their self-renewal and genome integrity and respond to multiple stresses at different stages of the cell cycle?

  • Record: found
  • Abstract: found
  • Editorial: found
Is Open Access

Why studying stress signalling in stem cells?

ScienceOpen Research

ScienceOpen

This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

Read this article at

ScienceOpen
Overview Bookmark

      Editorial content

      Stem cells are a unique subtype in an a developing or adult organism, which create all other cells through the process of differentiation. Stem cells are also characterized by their ability to divide in a potentially unlimited manner while fully retaining their stem cell characteristics (self-renewal). Because of these divisions, they are prone to multiple stresses and perils associated with maintaining their genome integrity at different stages of the cell cycle. Most stresses directly target the genome, by damaging the DNA or affecting faithful chromosome segregation. Some are metabolic or environmental toxins, but without direct DNA damage effect. While terminally differentiated cells are constantly replaced when damaged, every even the most minute effect onto stem cells is likely to become noticeable further downstream during tissue differentiation and homeostasis.

      This collection seeks to present research into various molecular and cellular mechanisms stem cells employ when responding to such stress. A large body of past and present research focuses on the embryonic stem cells, which are already cultured and studied for many years, but by now also adult somatic stem cells became the focus of stress studies. Presented are selected open-access publications from the year 2014 on.

      Author and article information

      10.14293/S2199-1006.1.SOR-LIFE.EAK7IA.v1