Ethics in digital resource processing and access are strongly coupled with human computer interaction because they produce trust between user and system. Over the past decades, we have seen a rapid increase of digital born resources in business applications where i.e. different stakeholders, ranging from patients, doctors to Data Scientists must cope with ethical aspects and regulations. Amongst others, innovative Model View Controller (MVC) based data management systems in the healthcare sector are analysing and managing an ever-growing, vast amount of sensitive data, enabling its efficient and comprehensive use in decision-making processes. E.g. in data-driven collaboration processes like drug development, caregiving or clinical patient monitoring. MVC is one of the most popular architectural patterns (Holzinger et.al 2010), which is the reason to investigate this design pattern further in terms of ethical aspects within human computer intractable systems. However, new regulations, like the GDPR have a huge impact on sensitive data management. However, ethical regulations could not first be considered by those who make use of information system functionalities, but must be an inherent part of considerations during software development process. This short paper will bring up and discuss ethical issues in decision making systems system software development, along with an existing ethic by design framework in the scope of health-related research projects.