233
views
0
recommends
+1 Recommend
1 collections
    0
    shares
       
      • Record: found
      • Abstract: found
      • Conference Proceedings: found
      Is Open Access

      Beatbox—A Computer Simulation Environment for Computational Biology of the Heart

      proceedings-article

      ,

      Visions of Computer Science - BCS International Academic Conference (VOCS)

      BCS International Academic Conference

      22 - 24 September 2008

      Computational biology, Cardiac electrophysiology, High Performance Computing

      Bookmark

            Abstract

            Despite over a century’s study, the trigger mechanisms of cardiac arrhythmias are poorly understood. Even modern experimental methods do not provide sufficient temporal and spacial resolution to trace the development of fibrillation in samples of cardiac tissue, not to mention the heart in vivo . Advances in human genetics provide information on the impact of certain genes on cellular activity, but do not explain the resultant mechanisms by which fibrillation arises. Thus, for some genetic cardiac diseases, the first presenting symptom is death. Computer simulations of electrical activity in cardiac tissue offer increasingly detailed insight into these phenomena, providing a view of cellular-level activity on the scale of a whole tissue wall. Already, advances in this field have led to developments in our understanding of heart fibrillation and sudden cardiac death and their impact is expected to increase significantly as we approach the ultimate goal of whole-heart modelling. Modelling the propagation of Action Potential through cardiac tissue is computationally expensive due to the huge number of equations per cell and the vast spacial and temporal scales required. The complexity of the problem encompasses the description of ionic currents underlying excitation of a single cell through the inhomogeneity of the tissue to the complex geometry of the whole heart. The timely running of computational models of cardiac tissue is increasingly dependant on the effective use of High Performance Computing (HPC), i.e. systems with parallel processors. Current state of the art cardiac simulation tools are limited either by the availability of modern, detailed models, or by their hardware portability or ease of use. The miscellany of current model implementations leads many researchers to develop their own ad-hoc software, preventing them from both utilising the power of HPC effectively, and from collaborating fluidly. It is, arguably, impeding scientific progress. This paper presents a roadmap for the development of Beatbox , a computer simulation environment for computational biology of the heart—an adaptable and extensible framework with which High Performance Computing may be harnessed by researchers.

            Content

            Author and article information

            Contributors
            Conference
            September 2008
            September 2008
            : 99-109
            Affiliations
            [0001]University of Liverpool

            Computer Science Department

            Ashton Building

            Ashton Street

            Liverpool

            L69 3BX, UK
            Article
            10.14236/ewic/VOCS2008.10
            68e42ef2-0fce-433f-9240-ab62e162283f
            © Ross McFarlane et al. Published by BCS Learning and Development Ltd. Visions of Computer Science - BCS International Academic Conference

            This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

            Visions of Computer Science - BCS International Academic Conference
            VOCS
            Imperial College, London, UK
            22 - 24 September 2008
            Electronic Workshops in Computing (eWiC)
            BCS International Academic Conference
            Product
            Product Information: 1477-9358BCS Learning & Development
            Self URI (journal page): https://ewic.bcs.org/
            Categories
            Electronic Workshops in Computing

            Comments

            Comment on this article