Nanotechnology-based cost-effective and simple diagnostic technology platforms

Cost-effective, simple, quick, and visual diagnostic technology platforms are the primary need for effectively diagnosing diseases with the minimum resources in low-income countries. We have developed a technology platform based on the magnetic nanoparticles coupled quantum dot immune-nano fluorescence assay (MNCQDINFA) for the visual detection of various cancers such as cervical, prostate (both patented), BCR-ABL-based leukaemia, Type I and Type II Ewing sarcoma with very low cost (Rs 120/sample). Another Nano-LAMP-based technology platform was IPR, which our group protected for the cost-effective (Rs 100/test) visual detection of animal and human viruses (BK Virus) that has already been extended to detect other viral systems. All these technology platforms are suitable for low-resource diagnostics setup due to their low cost (Rs 5-120/sample), rapid (2-4 hours), onsite (simple two-step test), visual color change (no equipment required), and easy to interpret the results (no need of the expert). These platforms’ simplicity and ease of use provide reassurance and confidence in their effectiveness. A glimpse of the success story during the validation of these technology platforms has shown the potential to change the diagnostics paradigm, especially for India’s rural hospitals and diagnostic centers.