The care residents suffer most of the winter dry, but there is a lack of specific standard or building regulation to guide the design and operation in the buildings that can avoid winter dry issue. To develop such a guide would need many evidence-based data, which is not readily available to this group of people. Collecting such data would rely on a specially designed and validated procedure. This study aims to develop and validate such a procedure that allows data to be collected in a real living environment to assess the effect of the room hygrothermal condition on the occupants’ skin condition and thermal comfort. The main effort is to minimize the disturbance to the subjects’ living and to carry out the data collection in a friendly and easy-understanding way.