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      Lumateperone treatment of Intermittent explosive disorder in those with Autism spectrum disorder

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            Abstract

            Introduction

            The use of lumateperone in reducing aggression in patients with autism spectrum disorder (ASD) and intermittent explosive disorder (IED) has not heretofore been described.

            Methods

            Case 1 is a non-verbal 18-year-old male with autism who presented with anger and aggression, biting his hands, intermittently grunting, and screaming. The patient's hostility subsided after ten days of establishing lumateperone 42mg nightly, in cross-titration with aripiprazole. Case 2 is a non-verbal 18-year-old male with a history of hypsarrhythmia, and Lennox-Gastaut syndrome, presented with similar aggression coincident increase in the frequency of myoclonic seizures. Management was initiated with 42mg of lumateperone nightly. Aggression and hostility were remitted after ten days and one month, respectively, for cases 1 and 2; however, the seizures persisted in Case 2.

            Conclusion

            Due to its dual action on dopamine D2 receptors and better side effect profile compared to other antipsychotics, the authors encourage a trial of lumateperone in treating aggression associated with ASD and IED.

            Content

            Author and article information

            Journal
            ScienceOpen Posters
            ScienceOpen
            2 June 2023
            Affiliations
            [1 ] Smell and Taste Treatment & Research Foundation Ltd, Chicago, USA;
            [2 ] Spartan Health Sciences University, Saint Lucia;
            Author notes
            Author information
            https://orcid.org/0000-0002-4541-3779
            Article
            10.14293/P2199-8442.1.SOP-.PZ9WEV.v1
            e7cc7a22-ee8d-400d-9175-de10cdf91d4c

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 2 June 2023
            Categories

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Medicine
            Child psychiatry,Autism spectrum disorder,Psychopharmacology,Intermittent explosive disorder,Lumateperone

            References

            1. Syed Alveena Batool, Brašić James Robert. The role of lumateperone in the treatment of schizophrenia. Therapeutic Advances in Psychopharmacology. Vol. 11:2021. SAGE Publications. [Cross Ref]

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