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      Development of Pharmacophore Model and Asymmetric Synthesis of Novel Tetrahydrofuran Derivatives Enroute to Triple Uptake Inhibitors As Anti-Depressant Agents

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      248th ACS National Meeting
      Antidepressants, Triple-uptake inhibitors, Pharmacophore development
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            Abstract

            Unipolar depression, caused by an imbalance of monoamine neurotransmitters in brain, is ranked as the most prevalent of all somatic and psychiatric illness. It is estimated that about 40 % of patients remains refractory to treatment thereby limiting the use of current antidepressant drugs. Moreover, because of relapse and unwanted side effects of existing drugs there is an unmet need to discover novel agents for the treatment of this devastating mental disorder. Current treatment aims at alleviating extraneuronal concentration of serotonin (5-HT) and /or norepinephrine (NE) (Figure 1). Tricyclic antidepressants were among the first class to have been discovered but due to their nonspecific side effects they have limited use in clinics. They have been largely replaced by second-generation antidepressants including selective serotonin reuptake inhibitors (SSRI, e.g., fluoxetine, Figure 2), selective norepinephrine reuptake inhibitors (NRI, e.g. reboxetine, Figure 2), and serotonin and norepinephrine reuptake inhibitors (SNRI, venlafexine, Figure 2).

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            Author and article information

            Conference
            ScienceOpen Posters
            ScienceOpen
            September 29 2014
            Author information
            https://orcid.org/0000-0003-3347-0538
            https://orcid.org/0000-0002-9605-6310
            Article
            10.14293/P2199-8442.1.SOP-CHEM.PE0IKA.v1
            6448f1cb-7a5b-4b03-bfc3-f718ebf8ba73

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            248th ACS National Meeting
            History

            Pharmaceutical chemistry
            Antidepressants,Triple-uptake inhibitors,Pharmacophore development

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