Islamic Religious Education is experiencing a significant transformation in the digital era and industry 4.0. This article explores the impact of using E-Learning and interactive technology in improving the quality of Islamic Religious Education learning. Involving an innovative approach, this research discusses how digital technology can be used to enrich students' learning experiences, facilitate wider access to teaching materials, and stimulate active engagement in the understanding of religious concepts. By utilizing case studies and field research, the author highlights the implementation of best practices in technology-based curriculum development for Islamic Religious Education. Utilizing E-Learning not only includes delivering material, but also introducing interactive elements such as online discussion platforms, simulations, and multimedia resources that support collaborative learning. The results of this research illustrate increased student motivation, better understanding of concepts, and development of critical skills through the use of interactive technology. Additionally, this article describes the challenges that may be encountered in implementing this approach and provides recommendations for overcoming these barriers. This research provides an in-depth view of the potential transformation of Islamic Religious Education through the integration of E-Learning and interactive technology. Pedagogical implications and future research directions are also discussed to provide guidance for practitioners, policy makers, and researchers in the fields of religious education and educational technology.