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      COVID-19 pathology and therapeutics

      Preprint
      In review
      research-article
      1 ,   2 ,
      ScienceOpen Preprints
      ScienceOpen
      SARS-CoV-2, ARDS, COVID-19, Pathology, Inflammation, Therapy
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            Abstract

            The SARS-CoV-2 pandemic has hit the world by surprise since its first outbreak in Wuhan, China resulting in millions of cases and thousands of deaths around the globe. The current situation is challenged by the lack of knowledge about the COVID-19 pathogenesis. Experts are not sure about the primary driver for mortality, is it the virus or the host immune response. The highly noted difference in outcomes reflects that individuals could react uniquely in response to infection where the inflammatory processes appear to impact the course and outcome of infection. Moreover, findings that came from COVID-19 autopsies suggest that SARS-CoV-2 pneumonia could transform to a severe form of ARDS. This paper aims at addressing briefly various complications observed in COVID-19 patients and providing a list of drugs that could be incorporated as a part of standard care for patients that are most severely affected by SARS-CoV-2 infection.

            Content

            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            9 June 2020
            Affiliations
            [1 ] School of Medicine, Al-azhar University for Girls, Cairo, Egypt.
            [2 ] Bachelor of Pharmaceutical Sciences, the British University in Egypt (BUE).
            Article
            10.14293/S2199-1006.1.SOR-.PP1SVRR.v1
            f62ed5c4-1e8f-48e5-b895-d9789b1f3252

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            Funding
            Not applicable Not applicable

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Medicine,Life sciences
            SARS-CoV-2,ARDS,COVID-19,Pathology,Inflammation,Therapy

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