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      COVID-19 pathology and therapeutics

      Preprint

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      ScienceOpen Preprints

      ScienceOpen

      SARS-CoV-2, ARDS, COVID-19, Pathology, Inflammation, Therapy

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          Abstract

          The SARS-CoV-2 pandemic has hit the world by surprise since its first outbreak in Wuhan, China resulting in millions of cases and thousands of deaths around the globe. The current situation is challenged by the lack of knowledge about the COVID-19 pathogenesis. Experts are not sure about the primary driver for mortality, is it the virus or the host immune response. The highly noted difference in outcomes reflects that individuals could react uniquely in response to infection where the inflammatory processes appear to impact the course and outcome of infection. Moreover, findings that came from COVID-19 autopsies suggest that SARS-CoV-2 pneumonia could transform to a severe form of ARDS. This paper aims at addressing briefly various complications observed in COVID-19 patients and providing a list of drugs that could be incorporated as a part of standard care for patients that are most severely affected by SARS-CoV-2 infection.

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          Author and article information

          Journal
          ScienceOpen Preprints
          ScienceOpen
          9 June 2020
          Affiliations
          [1 ] School of Medicine, Al-azhar University for Girls, Cairo, Egypt.
          [2 ] Bachelor of Pharmaceutical Sciences, the British University in Egypt (BUE).
          Article
          10.14293/S2199-1006.1.SOR-.PP1SVRR.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          Funding
          Not applicable Not applicable

          Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

          Medicine, Life sciences

          Therapy, SARS-CoV-2, ARDS, COVID-19, Pathology, Inflammation

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