Alternative medicines are vital in numerous sectors of global healthcare, including cardiovascular disease (CVD) treatment. This study investigates the role of alternative medicine (probiotic treatment) as an adjuvant source to lowering cholesterol and blood pressure in myocardial infarction (MI) and ischemia-reperfusion (IR) patients. The MI (n=100) and IR (n=100) were enrolled in this study from different private hospital sectors. The instructions were given to every patient of MI and IR to take a probiotic-rich diet for one month at least. Before and after probiotic-rich diet treatment, the data were analyzed by using SPSS-20 version software. Results showed a significant decrease in cholesterol and blood pressure after a probiotics-rich diet compared to before treatment. The study revealed the critical role of alternative probiotic treatment as an additional source in improving cardiovascular disease. However, large-scale studies are required to confirm and correlate with other disease risk factors .