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      STRA6 (vitamin A receptor), as a Novel binding receptor of COVID-19

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            Abstract

            A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been shown to be the main entry receptor of COVID-19, but here, in our docking analysis , we predicted and discovered a novel receptor called STRA6 that may play a critical role in the pathogenicity of COVID-19 and explain the common pre and post COVID-19 symptoms with uncertain etiology. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. In agreement to our findings, the main ligand of STRA6 (vitamin/retinol) was found to be significantly reduced during COVID-19 infection.

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            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            10 September 2021
            Affiliations
            [1 ] department of chemistry and biochemistry , faculty of science , Damietta university ,Egypt
            [2 ] public health department , Tuberculosis program, Director of shubra tuberculosis mobile team, First health cluster , ministry of health , Saudia Arabia
            [3 ] chemo and bioinformatics lab, Bio search institution , BSRI , Giza, Egypt, Federal university of Alfenas Brazil
            [4 ] zoology and Nematode department , Faculty of Agriculture , Al Azhar university , cario , Egypt
            Author notes
            Article
            10.14293/S2199-1006.1.SOR-.PP8LWHL.v1
            db5cfdbe-64bd-4656-9d38-ba320806012b

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .


            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Medicine,Chemistry
            retinoic acid receptors,molecular docking,spike proteins,COVID, SARS6,COVID-19,sars cov2

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