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      DIABETIC FOOT SYNDROME AS A POSSIBLE CARDIOVASCULAR MARKER IN TYPE 2 DIABETIC PATIENTS

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            Abstract

            Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality; in fact, some studies showed a higher prevalence of major, previous and new-onset, cardiovascular, and cerebrovascular events in diabetic patients with foot ulcers than in those without these complications. This is consistent with the fact that in diabetes there is a complex interplay of several variables with inflammatory metabolic disorders and their effect on the cardiovascular system that could explain previous reports of high morbidity and mortality rates in diabetic patients with amputations. Involvement of inflammatory markers such as IL-6 plasma levels in diabetic subjects confirmed the pathogenetic issue of the “adipovascular” axis that may contribute to cardiovascular risk in patients with type 2 diabetes. In patients with diabetic foot, this “adipovascular axis” expression in lower plasma levels of adiponectin and higher plasma levels of IL-6 could be linked to foot ulcers pathogenesis by microvascular and inflammatory mechanisms. The purpose of this review is to focus on the immune inflammatory features of DFS and its possible role as a marker of cardiovascular risk in type 2 diabetes patients.

            Author and article information

            Journal
            ScienceOpen Posters
            ScienceOpen
            20 March 2021
            Affiliations
            [1 ] Dept. of Pharm. Sci. & Tech., Institute of Chemical Technology, Mumbai, 400019, Maharashtra, India
            [2 ] DEPARTMENT OF PHARMACOLOGY, DELHI INSTITUTE OF PHARMACEUTICAL SCIENCES AND RESEARCH , NEW DELHI
            Author information
            https://orcid.org/0000-0003-4734-5682
            Article
            10.14293/S2199-1006.1.SOR-.PP8NTIN.v1
            b22f39be-89ec-4d6e-b079-3e2e776c5a67

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 20 March 2021

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Pharmacology & Pharmaceutical medicine
            Cardiovascular disease marker,Cardiovascular diseases,Type 2 diabetes,Diabetic foot syndrome,Diabetic foor

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