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      Assessing the therapeutic potential of APPs⍺ in a tau transgenic mouse model of Alzheimers disease

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            Abstract

            A large body of evidence indicates a neuroprotective and neurotrophic function for APPs⍺ not only in vitro, but also when expressed by AAV vectors in vivo such as in APP/PS1 transgenic AD model mice with Aβ-induced pathology. Previously, we could show that APPs⍺ rescued deficits of APP/PS1 in synaptic plasticity and spine density and also reduced plaque deposition. Thus, it is crucial to test a more general applicability of APPs⍺ as a treatment for AD and to assess whether APPs⍺ is also beneficial in mice with tau-induced pathology.

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            Journal
            ScienceOpen Posters
            ScienceOpen
            17 July 2020
            Affiliations
            [1 ] Institute for Pharmacy and Molecular Biotechnology, Universtiy of Heidelberg
            [2 ] Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg
            [3 ] Cellular Neurobiology, University of Braunschweig
            [4 ] Bioquant Center, University of Heidelberg
            [5 ] Bioquant Center, Unviersity of Heidelberg
            Article
            10.14293/S2199-1006.1.SOR-.PPA6V3N.v1
            49f715a5-42fd-4579-9c2d-7418591ec9f3

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .


            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Life sciences
            Alzheimer's disease, APP, Tau

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