A phytochemical screening was carried out on the ethanolic leaf extracts of Gongronema latifolium, Ocimum gratissimum and Vernonia amygdalina. Various combinations of the leaves were obtained. 50g each of Gongronema latifolium, Ocimum gratissimum and Vernonia amygdalina (GOV), 50g each of Gongronema latifolium and Ocimum gratissimum (GO), 50g each of Ocimum gratissimum and Vernonia amygdalina (OV), and also 50g each of Gongronema latifolium and Vernonia amygdalina (GV). Standard method of phytochemical screening was followed. The result of the phytochemical screening revealed that only saponin was present (+++) in all the combinations. Deoxy sugar was present in OV (+++), GOV (+), GV (++) and absent in GO (-). Terpenes was present in only GO (+++) and GV (++), while steroids was present in only OV (+) and GOV (+). Anthraquinones and cardiac glycoside were absent (-) in all the combinations. Absence of phytochemical when combined could be as a result of a particular bioactive compound masking the presence of another. It could also be that a particular phytochemical must have undergone chemical reaction that reduces the concentration of another phytochemical.