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      Linking structure and function in striatum using algebraic topology, digital microcircuit reconstruction and simulations of the healthy and diseased network

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          Abstract

          The relationship between the structure and network dynamics within the striatum is currently not well understood. We have applied algebraic topology to investigate the local structural connectivity in the striatum, and then used simulations to predict how structure shapes network dynamics. We used a full-scale digital reconstruction of the mouse striatal microcircuitry: both healthy and at different stages of Parkinson’s Disease (PD). These stages are characterized by successively modified healthy morphologies of the striatal projection neurons (SPN), including changes in dendritic spine count. We compared the distribution of topological motifs, in the form of directed cliques, between these microcircuits. The distribution of directed cliques in the healthy striatal microcircuits showed that striatal interneurons, despite only accounting for 5%, are crucial for the construction of high dimensional directed cliques. In PD networks the presence of directed cliques drastically decreased with the disease progression. We then used simulations to investigate whether these changes in structural connectivity affect functional connectivity. Signal transfer, especially correlation transfer, in the corticostriatal system was affected. We also found that the resulting changes in intrastriatal inhibition altered the correlations between the striatal projection neurons. Directed cliques already provided insight on structural and functional properties of neocortical micrucircuitry. Here we applied this topological approach to investigate striatal networks and highligthed important differences with respect to neocortex. Combining theory with simulations using data-driven in silico reconstructions will allow us to form quantitative predictions on how structure and network dynamics relate in health and disease.

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          Author and article information

          Journal
          ScienceOpen Posters
          ScienceOpen
          12 April 2021
          Affiliations
          [1 ] KTH Royal Institute of Technology, Department of Computational Science and Technology, Solna, Sweden
          [2 ] KTH Royal Institute of Technology, Department of Mathematics, Stockholm, Sweden
          [3 ] Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden
          [4 ] Karolinska Institute, Department of Neurobiology, Stockholm, Sweden
          Article
          10.14293/S2199-1006.1.SOR-.PPAEMIM.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

          Applied computer science, Computer science, Neural & Evolutionary computing, Geometry & Topology, Neurosciences, Mathematics, Life sciences

          striatum, algebraic topology, Parkinson’s Disease

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