This study aimed to examine the influence it is to study skills and academic-related stress in the academic performance of the students of the university. A descriptive research project was used. The study was carried out among students of engineering at the University of Dire Dawa. The study involved 400 students of the engineering bachelor's degrees, one hundred and, from the second to the fifth year, which has been evaluated for the academic stress and to study skills. A random sample is used to select objects for the study of the system. Three tools were used: Tool I: Socio-demographic Profile Sheet, Tool II: Study Skills Assessment Questionnaire, Tool III: Perceived Stress Scale. The results of this study showed that the students performed well in all the subjects, except for the time-management method and writing skills. More than two-thirds of the surveyed students have a low level of stress. Academic stress is higher in senior and female students. There was a negative correlation between the students ' stress and their study skills. Statistically significant relationships were found between academic performance, study skills, and the stress level of the students surveyed.