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      Paroxysmal sympathetic hyperactivity and the role of beta-blockers in moderate/severe traumatic brain injury: a scoping review protocol

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      ScienceOpen Preprints
      sympathetic hyperactivity, beta-blockers, traumatic brain injury


            INTRODUCTION Most cases of paroxysmal sympathetic hyperactivity (PSH) result from traumatic brain injury (TBI). Little is known about its pathophysiology and treatment, and several neuroprotective drugs are used including beta-blockers. Our study aims to collate existing evidence of the role of beta-blockers in the treatment of PSH. METHOD We will search MEDLINE, Web of Science, EMBASE, Cochrane, and Google Scholar. The search terms used will cover the following terms: paroxysmal sympathetic hyperactivity, traumatic brain injury and beta-blockers. No language or geographical restrictions will be applied. Two independent co-authors will screen the titles and abstracts of each article following predefined inclusion and exclusion criteria. If there is a conflict the two reviewers will find a consensus and if they cannot a third co-author will decide. Using a pre-designed and pre-piloted data extraction form, data from each included citation will be collected ( authors identification, study type, TBI severity, type of beta-blockers used, the dosage of the drug, clinical signs of PSH, Glasgow Coma Scale, Glasgow Outcome Scale , mortality , morbidity and length of stay). Simple descriptive data analyses will be performed and the results will be presented both in a narrative and tabular form. RESULTS The effectiveness of beta-blockers in post-TBI PHS will be evaluated through clinical signs of PHS(increased heart rate, respiratory rate, temperature, blood pressure, and sweating), Glasgow Coma Scale, and Glasgow Outcome Scale.. mortality, morbidity and length of stay. CONCLUSION At the end of this scoping review, we will design a systematic review with metaanalysis if there are a reasonable number of studies otherwise we will design a randomized controlled trial.


            Author and article information

            ScienceOpen Preprints
            15 October 2020
            [1 ] research department of association of future african neurosurgeons

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            sympathetic hyperactivity,beta-blockers,traumatic brain injury


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