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      Specification and regulation of the hypothalamic oxytocinergic system

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            Abstract

            The oxytocinergic and vasopressinergic systems regulate vital homeostatic functions as well as complex behaviors like social interaction. Despite their central neuromodulatory action, many details regarding the specification of the oxytocinergic and vasopressinergic circuits as well as the regulation of oxytocin (OXT) and vasopressin (AVP) release in the Central Nervous System remain unknown. Our laboratory has implemented a multidisciplinary approach combining genetic tagging for assaying OXT-containing vesicle dynamics and exocytosis, together with light-sheet ultraresolution microscopy and iDISCO+ tissue clarification methods for 3D circuit reconstruction (Madrigal & Jurado, 2021), in order to advance our current understanding of oxytocinergic and vasopressin function in modulating neuronal networks. We currently focus on analyzing the neurodevelopment of these systems and the dynamic properties of OXT and AVP release in the hypothalamus.Our results indicate a profound remodeling of the oxytocinergic and vasopressinergic systems during early postnatal stages that involves a switch of neuropeptide expression, which is recapitulated during vital experiences like aging or motherhood. Furthermore, OXT dynamics and release properties suggest distinct OXT-vesicle pools in the somatodendritic compartment of hypothalamic neurons which could be recruited upon diverse patterns of neuronal activity to orchestrate different aspects of behavior.

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            Journal
            ScienceOpen Posters
            ScienceOpen
            8 September 2022
            Affiliations
            [1 ] Institute of Neuroscience CSIC-UMH, San Juan de Alicante, 03550, Alicante, Spain;
            Author notes
            Author information
            https://orcid.org/0000-0003-1361-8750
            https://orcid.org/0000-0002-0011-6818
            https://orcid.org/0000-0003-3289-2624
            https://orcid.org/0000-0001-9906-0756
            https://orcid.org/0000-0001-9864-9307
            Article
            10.14293/S2199-1006.1.SOR-.PPEH7YL.v1
            fc89b8a0-9a32-42e0-a210-3110a3019249

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 8 September 2022
            Categories

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Life sciences
            Hypothalamus,Oxytocin,Vasopressin,Homeostasis,Social behavior,Aging,Vesicle dynamics

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