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      Reappraisal of Anoxic Spreading Depolarization as a Terminal Event in Brain Slices

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          Abstract

          In the present study we explored neuronal survival during oxygen-glucose deprivation (OGD) in slices of the barrel cortex using whole-cell patch clamp recordings and concomitant extracellular recordings of local field potential (LFP) ,and optical intrinsic signal (OIS). To this aim we used two types of neuronal survival assessment. In the first approach, we performed continuous recordings from a single neuron starting from control conditions and then through OGD and reperfusion. In the second approach, we sampled cells using short-term patch-clamp recordings in control conditions and during reperfusion following OGD of various durations (from 1 to 60 min).

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          Author and article information

          Journal
          ScienceOpen Posters
          ScienceOpen
          11 January 2021
          Affiliations
          [1 ] Laboratory of Neurobiology, Kazan Federal University, Kazan, 420008 Russia
          [2 ] Laboratory of Neurobiology, Kazan Federal University, Kazan, 420008 Russia. INMED/INSERM UMR1249, Aix-Marseille University, 163 Avenue de Luminy BP13, 13273 Marseille Cedex 09, France
          Article
          10.14293/S2199-1006.1.SOR-.PPEMAEZ.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

          Medicine

          Ischemia, Neuroscience, , Stroke, Diseases of the nervous system

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