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      Psychopathological descriptive model of hallucinogenic/psychedelic drugs effect in the treatment of depression and addictions

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      psychopathology, psychodelic drugs, depression
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            Abstract

            Introduction

            There is a growing and renewed interest in the use of hallucinogenic drugs in the treatment of psychiatric disorders, especially since the FDA approval of esketamine treatment for resistant depression.

            The response to hallucinogenic psychedelic substances (ayahuasca, psilocybin, LSD, ketamine) in the treatment of depression and addictions calls for a theoretical explanatory model.

            Objectives

            Provide a descriptive / explanatory psychopathological model of the response to treatment with hallucinogenic drugs based on the descriptions of the subjects and the comparison with other extreme life experiences.

            Methods

            Relevant published literature on subjective experiences in treatment with hallucinogenic drugs for depression and addictions is reviewed.

            It is compared with subjective experiences in life changing experiences.

            Results

            Intense emotional states, mystical-type experiences including feelings of oneness, transcendence, ineffability, and the complex emotion of awe seem to be consistently presented as psychic elements related to the efficacy of these treatments.

            The genetic and cultural (memetic) evolutionary value of these emotions in the cohesiveness of human groups and the genesis of affective symptoms, and in the recalibration of cognitions and emotions, is discussed.

            Conclusions

            The efficacy of hallucinogenic drugs used in the treatment of depression and addictions is accompanied by complex and varied emotions but with common psychopathological elements that could mediate their action.

            Content

            Author and article information

            Journal
            ScienceOpen Posters
            ScienceOpen
            2 May 2022
            Affiliations
            [1 ] Asuncion, Paraguay
            Author notes
            Author information
            https://orcid.org/0000-0001-9614-8007
            Article
            10.14293/S2199-1006.1.SOR-.PPFVG0C.v1
            1f21ca86-f35f-49c3-b04e-f5b52a4f9549

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 2 May 2022

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Clinical Psychology & Psychiatry
            psychopathology,psychodelic drugs,depression

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