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      Indomethacin in COVID-19, more than just NSAID

      Preprint
      In review

        , 1 , 2

      ScienceOpen Preprints

      ScienceOpen

      SARS-CoV-2, COVID-19, Cytokines , Indomethacin , PPAR- gamma , HIF-1 alpha

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          Abstract

          This article aims to direct some interest on the positive role that Indomethacin could play in COVID-19. We relied on available evidence from the present literature and results of few clinical trials. We first discussed briefly, the documented antiviral activityof Indomethacin on coronaviruses and other viruses then moved to talk abouthow it could control the exaggerated immune responsefrequently reported during SARS-CoV-2infectionthrough the modulation ofthe PPAR-γ & HIF-1α axis. At the end, we posted the results of some clinical trials that we consider promising.Itisimportant to note that our article does not carry a specificrecommendation forIndomethacinas a global treatment for COVID-19, but we do believe it deservesto be implemented in more clinical trials.

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          Author and article information

          Journal
          ScienceOpen Preprints
          ScienceOpen
          3 April 2021
          Affiliations
          [1 ] Bachelor of Pharmacy, the British University in Egypt (BUE)
          [2 ] Faculty of Medicine, Al-Azhar University for Girls, Cairo, Egypt
          Article
          10.14293/S2199-1006.1.SOR-.PPJ4IMY.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

          Medicine, Life sciences

          HIF-1 alpha , SARS-CoV-2, COVID-19, Cytokines , Indomethacin , PPAR- gamma

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