An attractive approach to vaccination is presented by nucleic acid vaccines. These vaccines based on DNA or RNA encoded with specific antigen and generally regarded as safe, effective which can mimic live infection with low rise of reversion to virulence. RNA vaccines generally elicit humoral as well as cellular immune response. Personalized medicine is the new paradigm of medical science for targeting specific characteristics of each individual by using their genetic profile to identify particular nature of the medical condition and design a unique treatment for each patient. Cancer immunotherapy stimulates a host antitumor immune response which can able to lead tumor shrinkage for the improvement of clinical outcomes in cancer patients. Eradication of the large tumor by active immunotherapy is the biggest challenge, to overcome this challenge combination therapy of mRNA vaccine with radiation can be effective. mRNA as a vaccine have many advantages including large scale production under GMP conditions is comparatively easy and robust, thats why inexpensive in contrast to the other biopharmaceuticals. The tumor antigens are recognizing by the immune system and this is the basis for cancer immunotherapy development.