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      Data Fabrication and Data Falsification in the paper entitled "Regulation of DARPP-32 dephosphorylation at PKA and Cdk5-sites by NMDA and AMPA receptors", authored by Nishi, A., Bibb, J.A., Matsuyama, S., Hamada, M., Higushi, H., Nairn, A.C. and Greengard. P., and published in the Journal of Neurochemistry. [J. Neurochem. (2002) Vol. 5, pp832-841].

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          Abstract

          The paper entitled "Regulation of DARPP-32 dephosphorylation at PKA and Cdk5-sites by NMDA and AMPA receptors", authored by Nishi, A., Bibb, J.A., Matsuyama, S., Hamada, M., Higushi, H., Nairn, A.C. and Greengard. P., and published in the Journal of Neurochemistry. [J. Neurochem. (2002) Vol. 5, pp832-841] describes the study the effects of ionotropic glutamate NMDA and AMPA receptors on DARPP-32 phosphorylation in neostriatal slices and purported to show that activation of NMDA and AMPA receptors caused the decrease of phosphorylations of threonone 34 and threonine 75 DARPP-32 mediated by Ca 2+-dependent activation of calcineurin and protein phosphatase-2A respectively. However, no supporting scientific results were provided. Figures 1A, 1B, 1C and 1D are duplicates of each other. With exactly the same figures depicting exactly the same immunublots, the authors somehow came up with different bar charts that supposedly quantify the extent of DARPP-32 phosphorylation levels under different conditions. Figures 3A and 3C are also duplicates of each other. It is not clear how the reviewer(s) and the Editor of the Journal of Neurochemistry could have missed the glaring evidence of Data Fabrication and and Data Falsification.

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          Author and article information

          Journal
          ScienceOpen Preprints
          ScienceOpen
          2 February 2020
          Affiliations
          [1 ] Nachbraht Biomedical Research Institute
          Article
          10.14293/S2199-1006.1.SOR-.PPK55GM.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

          Philosophy of science, Biochemistry, Neurosciences

          DARPP-32, Protein phosphatase-1, Protein phosphatase-2A, Calcineurin, NMDA, Scientific fraud, AMPA, Data Fabrication, Data Falsification, Scientific Misconduct

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