The present investigation is to find out the Adjustment of Dire Dawa University Lecturers concerning their gender. The sample consisted of 120 lecturers out of which 60 were male and 60 were female. For this purpose of investigation, the Teachers Adjustment Inventory was used. The obtained data were analyzed through the "t" test to know the mean difference between the lecturers concerning their gender. The result shows that there is no significant difference in University, Teaching, and Overload course adjustment of male and female Dire Dawa university Lecturers. But there is a significant difference in conducting research adjustment of male & female Lecturers at 0.05 levels. It means males Conducting research adjustment are better than female Lecturers.