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      Evaluation of Cosmetic Properties of Natural Ingredients in the Trás-os-Montes area: a PhD Project

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      Genotoxicity, Almonds, Grapes, Elderberry, Olives, Antigenotoxicity, Cosmetics, Natural Ingredient
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            Abstract

            The term cosmetics refers to a product applied to the body for the purpose of beautifying, cleansing or improving appearance and enhancing attractive features. The natural cosmetics market has grown since the consumer took consciousness of the concept of natural-based ingredients. A great number of cosmetics have noxious and chemically-potent substances and have an ecological impact on the environment. A study performed by the Danish Council THINK Chemicalsfound that in total 65 chemicals of concern were found in 39 products. This means consumers are exposed to these chemicals, perhaps in a daily basis. They also found that three products contained illegal ingredients in the European Union. Thus, the use of natural and organic cosmetics becomes increasingly important. This requires a strong investigation into the benefits that fruits and plants can bring to health. The PhD project will focus on four natural ingredients common in the Trás-os-Montes area: almond (Prunus dulcis), elderberry (Sambucus nigra), olive (Olea europaea) and grapes (Vitis vinifera). The general purpose of this PhD project is to evaluate the cosmetic properties of the natural ingredients towards the DNA integrity promotion. Additionally, it is intended to evaluate genoprotection, longevity and prolificacy of the natural ingredients in Drosophila melanogaster. The short life cycle, the distinct developmental stages, the availability of various tools and reagents, known genome sequence and the physiological similarity of Drosophila with humans make them an excellent in vivo model organism to rapidly test toxicity in whole organism and elucidate the molecular mechanisms underlying the toxicity. The natural product with the best result will be used to evaluate genoprotection in human lymphocytes. These are used as a surrogate tissue, as they are easily obtained, in large numbers, do not require cell culture, are diploids and are almost all in the same phase of the cell cycle. This project is in an initial phase and lacks results, which will be available along this year.

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            Author and article information

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            ScienceOpen Posters
            ScienceOpen
            8 March 2021
            Affiliations
            [1 ] Department of Genetics and Biotechnology and CECAV, University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5000 Vila Real,Portugal
            Author information
            https://orcid.org/0000-0002-8287-1357
            https://orcid.org/0000-0003-4461-7021
            Article
            10.14293/S2199-1006.1.SOR-.PPLZ4CW.v1
            4f10208a-10b5-4208-939d-0b5224aa2f00

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 8 March 2021

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Toxicology,Genetics
            Genotoxicity,Almonds,Grapes,Elderberry,Olives,Antigenotoxicity,Cosmetics,Natural Ingredient

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