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      E.L.S.A: E. coli Learning Suboptimal Acclimatization

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            Abstract

            Low intrinsic stability has marred the production of psychrophilic proteins in commonly used mesophilic systems. This may lead to a lopsided bias towards the expression of the few psychrophilic proteins which can manage a stable structure at those temperatures. Of the two possible approaches to help counterpoise the expression in favour of most psychrophilic proteins, the approach we have taken is to develop a new psychrophilic host. Rather than characterizing novel strains, we plan on converting a highly characterized system in synthetic biology, E.coli, by introducing genes that confer cold-tolerance to it thereby reducing dependency on regular mesophilic hosts and possibly making it the model system for cold temperature-based systems.

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            Author and article information

            Journal
            ScienceOpen Posters
            ScienceOpen
            21 February 2021
            Affiliations
            [1 ] Indian Institute of Science Education and Research - Bhopal, India
            Author information
            https://orcid.org/0000-0003-3492-0203
            Article
            10.14293/S2199-1006.1.SOR-.PPMEWLW.v1
            02ba50ef-58f6-4194-9914-649827f49305

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 21 February 2021

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Microbiology & Virology
            Microbiology,Recombinant Protein Production,Psychrophilic Enzymes,Synthetic Biology,Chaperones

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