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      Polycyclic Aromatic Hydrocarbons (PAHs) Food Contamination: A contributing Factor to Rising Carcinogenicity

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            Abstract

            Polycyclic aromatic hydrocarbons (PAHs) constitute a large class of organic compounds that are composed of two or more fused aromatic rings. They are primarily formed by incomplete combustion or pyrolysis of organic matter and during various industrial processes. PAHs generally occur in complex mixtures which may consist of hundreds of compounds (Abou-Arab et., al 2002). Humans can be exposed to various chemicals including ubiquitous polycyclic aromatic hydrocarbons (PAHs) mostly through food consumption and/or inhalation (Andrea Polachova et. al. , 2020). The human absorption of PAHs follows different routes. While for non-smokers, the major route of exposure is through the combustion of food, for smokers the contribution from smoking may be significant. Food can be contaminated from environmental sources that are present in the air, soil, or water, by industrial food processing methods (e.g heating, drying, and smoking) and by home food preparation (e.g grilling and roasting). The Scientific Committee on food SCF (2005) reported that 15 priority PAHs out of the 33 PAHs which were considered in their assessment showed clear evidence of mutagenicity/genotoxicity in somatic cells in experimental animals in vivo and with the exception of benzo(ghi)perylene also showed clear carcinogenic effects in various types of bioassays in experimental animals. Teratogenicity is caused in pregnant women and their developing fetuses are particularly susceptible populations to environmental contaminants because alterations in hormone physiology during gestation can have adverse consequences on the health of the pregnancy (Amber L. Cathey et al ., 2020). This, SCF (2005) conclusively reported that these compounds may be regarded as potentially genotoxic and carcinogenic to humans and thus represent a priority group in the assessment of the risk of long-term adverse health effects following intake of PAHs.

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            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            29 October 2020
            Affiliations
            [1 ] Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russian Federation
            [2 ] University of Agriculture Makurdi, Benue State-Nigeria
            Article
            10.14293/S2199-1006.1.SOR-.PPRO2AU.v1
            773624bc-5a9b-41ad-bd0c-2145e8c4c8e8

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .


            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Life sciences
            Polycyclic Aromatic Hydrocarbons (PAHs), Food, Occurrence, Exposure, Toxicity, Cancer

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