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      Senolytic Activity of Selected NRF2-Interacting Natural Compounds

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      Phytocompounds , Senolytics, SASPs, Gerotherapeutics

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          Abstract

          Cellular senescence is a process that results in irreversible cell-cycle arrest acting as an autonomous tumor-suppressor mechanism. During senescence, cells develop distinctive metabolic and signaling features, together referred to as the senescence-associated secretory phenotypes (SASPs). The SASPs are implicated in several aging related pathologies, including various disorders and malignancies. Senolytics are rejuvenative compounds that eliminate harmful SASPs, which accumulate by evading immunosurveillance and activate inflammatory pathways. Several senolytic compounds, especially dietary plant metabolites that activate the cytoprotective NRF2 (nuclear factor erythroid derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been shown to target senescent cells that escape immunosurveillance. In this study, we have performed a systematic review of in vitro and in vivo effects of selected NRF2-interacting phytocompounds: quercetin, fisetin, hesperidin, epicatechin, metformin and resveratrol on senescent cells and evaluated their prospective utilization in gerotherapeutics.

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          Author and article information

          Journal
          ScienceOpen Posters
          ScienceOpen
          6 April 2020
          Affiliations
          [1 ] Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Bangladesh
          Article
          10.14293/S2199-1006.1.SOR-.PPSB8HH.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

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